PhD Gene Expression: The University of Manchester

Course description

PhD programmes are based on individual research projects that last 3 or 4 years, working with a specific academic supervisor (principle investigators). Applicants are specifically matched with a principle investigator based on their research interests and background.

Manchester is a major centre for research in gene expression and intracellular signalling. Gene expression can be divided into three main events, beginning with the transcription of a gene to produce an RNA precursor. This is processed to produce a mature mRNA that is then translated to produce the protein product. Members of the group are engaged in the study of all of these events at the molecular, cellular and organismal levels. Gene expression is stringently regulated and is the end point of many intracellular signalling cascades. Several members of the group are interested in the mechanisms of signal transduction and how they mediate specific responses in gene expression profiles. A range of processes are under investigation, including development, cancer, stress response and biological clocks. A variety of model organisms/systems are used, from yeast to mammals, to study different aspects of gene expression including signal transduction, chromatin, transcriptional regulation, RNA processing/biology and translation.

Career opportunities

In terms of career progression, the majority of their postgraduate students remain in research, while others move into related areas such as education, information technology, consultancy and management, helped by the  comprehensive skills training they gain during their programme of study.

Entry requirements

Academic entry qualification overview:

The standard entry requirement for PhD study is a First or Upper Second class honours degree, or the overseas equivalent, in a relevant subject. In certain circumstances, a Lower Second class honours degree supplemented by a Masters degree, or appropriate relevant work experience, may be acceptable.

English language:

For PhD applicants whose first language is not English an IELTS score of 6.5, TOEFL 577 (paper based), TOEFL 233 (computer based) or TOEFL 90 (internet based) is required as a minimum.