PhD Organelle Function: The University of Manchester

Course description

PhD programmes are based on individual research projects that last 3 or 4 years, working with a specific academic supervisor (principle investigators). Applicants are specifically matched with a principle investigator based on their research interests and background.

Specific mechanisms promote the correct folding and assembly of newly synthesised proteins and ensure that these molecules are transported to their appropriate compartment within a eukaryotic cell. Many diseases, such as cystic fibrosis, are related to defects in one or more of these processes and their work is focused on two broad themes. The first encompasses how proteins are transported into and across the endoplasmic reticulum (ER) and mitochondrial membranes and how they are folded and assembled in these organelles. The second involves defining the machinery and mechanisms responsible for the sorting and transport of proteins between the different compartments of the endomembrane system and in maintaining organelle identity. Their goal is to understand the underlying mechanisms for each process and how they are regulated. This knowledge will provide them with an intellectual framework within which specific diseases can be studied.

Career opportunities

In terms of career progression, the majority of their postgraduate students remain in research, while others move into related areas such as education, information technology, consultancy and management, helped by the  comprehensive skills training they gain during their programme of study.

Entry requirements

Academic entry qualification overview:

The standard entry requirement for PhD study is a First or Upper Second class honours degree, or the overseas equivalent, in a relevant subject. In certain circumstances, a Lower Second class honours degree supplemented by a Masters degree, or appropriate relevant work experience, may be acceptable.

English language:

For PhD applicants whose first language is not English an IELTS score of 6.5, TOEFL 577 (paper based), TOEFL 233 (computer based) or TOEFL 90 (internet based) is required as a minimum.